What do you know about the novel Coronavirus that is causing a health emergency?

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans.

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22 COMMENTS

  1. "Covering my mouth when coughing or sneezing"??
    You mean to protect others??
    But what about me?.. Me myself and I?? What about if i don't wanna cover my mouth because i'm already infected and i worry about MY health. What about me me me?…

  2. Korona virus di sebabkan oleh udara dingin yang membuat sel darah merah di dalam tubuh jadi tidak aktif sehingga memperlambat peredaran darah dan untuk menghindari agar tidak terinfeksi virus corona biasakan diri untuk mandi sengatan panas matahari ….😷

  3. The animals and the birds do not go to any universities nor do they earn any degree; if human being too in spite of his education leads a life of animals and beats then what is the use of human life? Does it lie in amassing wealth? Honey bees too amass sweet nectar from flowers bit by bit and build a honey coomb. Is earning wealth the specialty of human life? Honey bees too are amassing wealth.

  4. Totally and dangerously OUT-OF-DATE! "Limited geographic spread" is wrong, absolutely wrong!! The publishers need to delete this now-dangerous pack of ignorance and untruths.

  5. Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice.

    Keyaerts E, et al. Antimicrob Agents Chemother. 2009.

    Authors

    Keyaerts E1, Li S, Vijgen L, Rysman E, Verbeeck J, Van Ranst M, Maes P.

    Author information

    1Laboratory of Clinical Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B3000 Leuven, Belgium.

    Citation

    Antimicrob Agents Chemother. 2009 Aug;53(8):3416-21. doi: 10.1128/AAC.01509-08. Epub 2009 Jun 8.

    Abstract

    Until recently, human coronaviruses (HCoVs), such as HCoV strain OC43 (HCoV-OC43), were mainly known to cause 15 to 30% of mild upper respiratory tract infections. In recent years, the identification of new HCoVs, including severe acute respiratory syndrome coronavirus, revealed that HCoVs can be highly pathogenic and can cause more severe upper and lower respiratory tract infections, including bronchiolitis and pneumonia. To date, no specific antiviral drugs to prevent or treat HCoV infections are available. We demonstrate that chloroquine, a widely used drug with well-known antimalarial effects, inhibits HCoV-OC43 replication in HRT-18 cells, with a 50% effective concentration (+/- standard deviation) of 0.306 +/- 0.0091 microM and a 50% cytotoxic concentration (+/- standard deviation) of 419 +/- 192.5 microM, resulting in a selectivity index of 1,369. Further, we investigated whether chloroquine could prevent HCoV-OC43-induced death in newborn mice. Our results show that a lethal HCoV-OC43 infection in newborn C57BL/6 mice can be treated with chloroquine acquired transplacentally or via maternal milk. The highest survival rate (98.6%) of the pups was found when mother mice were treated daily with a concentration of 15 mg of chloroquine per kg of body weight. Survival rates declined in a dose-dependent manner, with 88% survival when treated with 5 mg/kg chloroquine and 13% survival when treated with 1 mg/kg chloroquine. Our results show that chloroquine can be highly effective against HCoV-OC43 infection in newborn mice and may be considered as a future drug against HCoVs.

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